Element 12 Magnesium

Magnesium citrate is a highly soluble form of magnesium known for its efficient intestinal absorption. It contributes to neuromuscular relaxation by regulating calcium transport in muscle cells and supporting the activity of neurotransmitters involved in calming the nervous system. While it can act as a mild cathartic to support normal bowel function, its primary role in this formula is to enhance relaxation, reduce physiological stress, and promote mental calmness—foundational for restorative sleep and recovery processes.

Magnesium amino acid chelate is a form of magnesium bound to amino acids, which significantly increases its bioavailability and reduces gastrointestinal discomfort. This form directly supports normal muscle contraction and relaxation, as well as proper nerve impulse transmission, both critical for neuromuscular function. Additionally, it assists in maintaining digestive efficiency, ensuring that magnesium and other nutrients in the formula are effectively absorbed and utilized at the cellular level.

Magnesium glycinate, where magnesium is chelated with glycine, is highly absorbable and minimally laxative. It supports relaxation and promotes sleep by enhancing gamma-aminobutyric acid (GABA) activity in the central nervous system, a key inhibitory neurotransmitter that reduces neuronal excitability. Beyond its calming effects, it contributes to normal muscle function, nerve conduction, and cellular energy metabolism, complementing the other forms of magnesium in the formula for a comprehensive physiological effect.

Element 12 includes biologically active vitamins B1, B2, B3, B5, B6 (pyriodoxal-5 phosphate monohydrate) and B6 (pyridoxine hydrochloride), which bypass the need for enzymatic conversion and are immediately available for cellular processes. These vitamins play a crucial role in energy metabolism, cofactor functions in neurotransmitter synthesis, and the modulation of stress response pathways. By supporting efficient magnesium utilisation, active B vitamins enhance neuromuscular function, cognitive performance, and overall metabolic balance.

Folic acid is essential for one-carbon metabolism, which underpins DNA synthesis, repair, and methylation. Combined with the other ingredients in Element 12, folic acid contributes to nerve health by supporting the synthesis of neurotransmitters and maintaining neuronal integrity. Its role in cellular proliferation and repair further complements magnesium and B vitamins, promoting optimal neurological function and overall cellular resilience.

Zinc is a trace element critical for the catalytic activity of over 300 enzymes involved in protein and nucleic acid metabolism. It contributes to normal brain function, immune regulation, and cellular signalling pathways. In combination with magnesium, selenium, and B vitamins, zinc supports neuroprotection, neurotransmitter regulation, and overall cellular homeostasis, making it essential for both cognitive and physiological health.

Selenium is a key component of selenoproteins, which act as antioxidants to protect cells from oxidative damage caused by free radicals. It supports thyroid hormone metabolism, cardiovascular function, and immune system efficiency, and contributes to neurological protection. In men, selenium is critical for fertility, and in older adults, it has been associated with reduced cognitive decline. Its inclusion in Element 12 supports broad-spectrum cellular protection and metabolic support.

Vitamin D3 is a fat-soluble vitamin that regulates calcium and phosphorus homeostasis, promoting bone mineralization and optimal muscle function. It also modulates immune responses and supports anti-inflammatory pathways. When combined with magnesium, zinc, selenium, and B vitamins, vitamin D3 enhances neuromuscular coordination, cellular signalling, and overall physiological resilience, making it a key nutrient for comprehensive health support.